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Events in R411

20230814

Welcome 黃楷 陳世庭 王廷悠 謝昌宏 for NYCU life summer camp

20230717

Welcome TDTU internship students visiting

20230701

Welcome 劉怡欣 劉姍如join us

20230214

​Welcome 楊世毓 (醫學大一) join us

20230201

升等副教授

20220910

Publish: antivirals against all variants of SARS-CoV-2 by blocking viral binding to the host cells and spike-mediated fusion.

20220901

-Congratulation Zoe、Hani、Jo、Rolling、Meimei graduate!

-Lab Retreat in 美麗的花蓮

-Congratulation Zoe receive NYCU Elite PhD scholarship.

-Welcome 邱子筠、吳立萱、吳泯儒join us

20220818

榮獲國科會吳大猷先生紀念獎:)

https://www.nycu.edu.tw/news/3932

20220804

榮獲美國AII達文西國際發明展金牌獎

20220715

Welcome 黃依岑(醫技) join us for undergraduate projects

20220501

​吳思賢(醫技)-大專生科技部計畫

20220415

Welcome Abhi join us for PhD study

20220331

榮獲國際阿基米德發明展金牌

https://www.nycu.edu.tw/news/3573/

20211017

Welcome 陳羿妘(醫學) join us for undergraduate projects

20210928

榮獲陽明交通大學優良導師:)

20210920

Article accepted in Biosensors and Bioelectronics (EBV sensor)

20210909 

Article accepted in PNAS (functions of EBER2)

20200901

Welcome 林榆涵、邱雅彙 join us

​Congratulation 毛翎、李晉豪、蘇沛瑜graduate!

20210220

Welcome 呂韋萱(醫技) join us for undergraduate projects

20200920

Welcome 陳一華(醫學) join us for undergraduate projects

20200815

Welcome 周壬渼、蔡若翎 join us

20200731

Welcome 張琳翔、張庭偉、陳一華、林得鴻for summer internship

20200701

Welcome陶定雨(生科)、劉子晴(醫技)、陳怡秀(醫技)、吳思賢(醫技) join us for undergraduate projects

20200226

Published in Journal of Virology (identify new EBV strains)

20200210

Welcome 林家安(醫技)、莊筑甯(醫技)、余麗文(醫技)、賴金承(醫學) join us for undergraduate projects

20200120

Welcome TIGP PhD student Ivonne Lee join us

20191230

Welcome 洪若寧(醫技) join us

20191105

Welcome TIGP PhD student Ivonne Lee! (rotation)

20191026-31

International collaboration with Applied science and Pharmaceutical departments of TDTU (孫得勝大學)@ Vietnam.

20191001

The opening of R411's Website!

20190928

Whole Lab's database complete

榮獲陽明大學良師益友獎

20190930

Published in PloS One (functions of miRNA in EBV-transformed B cells isolated from patients).

20190906

Published in Nature Microbiology (ncRNA EBER regulates viral lytic replication and its effects on the environmental cells).

20190901

Welcome 毛翎, queen of 3D culture.

20190801

Welcome 李晉豪、蘇沛瑜、ChiaChia

2019July

Welcome summer students

Welcome international students

20190301

Welcome 張舒雅(醫技)

20190201

Published in Journal of Virology (EBV+ B cell movement).

20181101

Published in Plos Pathogens (EBV vaccine)

20180901

Welcome 翁立洋、洪瑄茌

20180815

Eventually our lab is ready to be used.

20180701

Welcome 5 Summer students

20180501

Congratulation! We won the MOST Young Scholar Fellowship! (哥倫布計畫得主) 

20180301

Published in Nucleic Acids Research (new ORF of EBV)

Virus.8.png
Who we are?
Virus.7.png

We are a very strong team for studying the viral genetics and the pathogenic roles of the giant virus. We use Epstein-Barr virus (EBV) as model. Our group leader, Dr. Ming-Han Tsai (蔡明翰) is exactly the person who had successfully constructed the five standard EBV strains (total 7 strains) in the world (including all the carcinoma EBV strains). Meanwhile, our PI has the strong collaboration with Prof. Dr. Delecluse at DKFZ/Germany, who established the elegant system to modify the EBV viral genome.

​We have strong collaboration with different research groups and hospitals in Taiwan and globally and wish to eradicate the cancers caused by EBV in the next decades. At first, we are focusing on the pathogenic roles of EBV in gastric cancer and we will expand our research toward other EBV-associated carcinomas. Importantly, EBV is the last major human tumor virus that is still barely understood; so far we still don't have drugs or vaccines against EBV.

Due to the strong techniques for constructing giant DNA virus, we are also genetically modifying these giant DNA viruses for different applications and seeking for the opportunities for the bio-pharmaceutical businesses. 

Our researches are kindly supported by MOST Young Scholar Fellowship for 5 years. We sincerely invite the highly motivated students to join our research team and enjoy the researches together!

In The News

NCTU+NYMU=YMCT?

We are going to unite with NCTU and become a new university in the next August. Well, YMC"A" perhaps is a simple one to remember?​ Sep, 18, 2019

The Outbreak of new coronavirus (COVID-19), live photo

World Health Organization (WHO)

https://experience.arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd

Human Herpesvirus may lead to bipolar, depression?

Activating Hpothalamic-pituitary-adernal axis!?

https://www.cell.com/iscience/pdf/S2589-0042(20)30372-2.pdf

https://www.medicalnewstoday.com/articles/322752#How-HHV-6-may-cause-depression,-bipolar

Unfortunately, COVID-19 kills 1.5 millions now (2020/12/08)

COVID-19 Pandemic

https://www.who.int/emergencies/diseases/novel-coronavirus-2019

EBV is for the bad symptoms after COVID-19 infection! (2021/09)

COVID-19 Pandemic-EBV

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233978/

EBV causes inflammation after COVID-19 infection! (2021/09)

COVID-19 Pandemic-EBV

https://pubmed.ncbi.nlm.nih.gov/34035353/

Epstein-Barr virus reactivation may be the cause of long COVID symptoms (2021/06)

COVID-19 Pandemic-EBV

https://www.news-medical.net/news/20210623/Epstein-Barr-virus-reactivation-may-be-the-cause-of-long-COVID-symptoms.aspx

EBV and human autoimmune disease had been confirmed (2022/01)

Science: clinical researches suggest that EBV as the leading cause for Multiple sclerosis

https://www.science.org/doi/10.1126/science.abm7930

https://www.science.org/doi/10.1126/science.abj8222

The New version of CRISPR-Cas9 with low off-target effects.

Nature. Believe it or not, this CRISPR fused with a viral protein that makes it possible.

https://www.nature.com/articles/s41586-019-1711-4

The outbreak of ASFV

Now only Japan and Taiwan are free from African Swine Fever virus that causes 100% death rate of the infected pigs. Sep, 01, 2019

The Receptor of Chikungunya had been identified.

Published in Nature and Cell. It's FHL1.

https://www.nature.com/articles/s41586-019-1578-4

https://www.ncbi.nlm.nih.gov/pubmed/31080063

Human error leak of lab virus now a substantial probability.

https://www.express.co.uk/news/science/1183758/

Nasopharyngeal Carcinoma is caused by specific EBV strain! 

Why all people are EBV-positive but some of them get cancers? Now is the answer: certain EBV strains cause human carcinomas! 

https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32049

Please also visit our official website: Department of Microbiology and Immunology, National Yang-Ming University (IMI, NYMU)
請您也蒞臨我們官方網頁: 國立陽明交通大學 微生物及免疫學研究所(微免所) 蔡明翰老師 腫瘤癌症病毒及病毒生物科技實驗室

https://imi.nycu.edu.tw/index.php/ming-han-tsai-c/

The confirmation of EBV in autoimmine diseases 

System lupus erythematosus    (SLE), multiple sclerosis (MS), are considered caused by EBV infection right now. (Nature genetics) 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022759/

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