Tsai, Ming-Han (蔡明翰 老師)
"Tumor viruses, EBV, and viral biotechnology lab"
Let’s Eradicate Virus-Induced Cancers and Diseases Together!
Let’s Harness Viral Power to Transform the World!
國立陽明交通大學 微生物及免疫學研究所 蔡明翰老師 (建議用電腦觀看此網頁)
If you have questions for us, please don't hesitate to leave your message.
Events in R411
202510
Congrat Zoe and Emily won oral and poster competition in TSME (Taiwan Society of Microbial Ecology).
202509
-Article Accepted in Chemical engineering journal (CEJ, ranking 3%) (Plasma-derived green materials for antivirals)
-Congrat: Jo-Ning initiates virology PhD study at HZI in Germany.
-Congrat: Eugenia accepted by London King's colleage, UK, for Stem cell research.
-Award: 第一季優良論文
-Award: 陽明交大優良教學獎
-Welcome: Mike and Jessica join our lab.
202507
-Invited Speaker at 台北生技展: 靈芝抗病毒藥物之開發
-Invited Speaker at AsiaPharm VI conference
202503
-Welcome TDTU exchange student Phat
-Welcome Sally, Minh, and Vy join our lab.
-Article Accepted in International Journal of Biological Macromolecules (Ranking 6%) (novel FDA-approved fungi proteinbinds to herpesviral gB and neutralized viral fusion)
202501
-Congrat Zoe be PhD candidate.
202410
Spreading EBV knowledge.
-Invited Speaker at Japanese Society of Hematology (JSH), Kyoto
-Invited Speaker at University of Nagoya
202409
-Welcome 曹維天(生科) join us for lab internship
202408
-Award Fellow of Higher Education Association (FHEA)
202405
-Welcome Eugenia join us for lab internship
202402
-Welcome Kei and Jade join us
202305
Welcome 黃學紘 (醫學) join us
202302
升等副教授
202209
-Publish: antivirals against all variants of SARS-CoV-2 by blocking viral binding to the host cells and spike-mediated fusion.
-Congratulation Zoe、Hani、Jo、Rolling、Meimei graduate!
-Lab Retreat in 美麗的花蓮
-Congratulation Zoe receive NYCU Elite PhD scholarship.
-Welcome 吳立萱join us
20220818
國科會吳大猷先生紀念獎
https://www.nycu.edu.tw/news/3932
20220804
美國AII達文西國際發明展金牌獎
20220501
吳思賢(醫技)-大專生科技部計畫
20220415
Welcome Abhi join us for PhD study
20220331
榮獲國際阿基米德發明展金牌
https://www.nycu.edu.tw/news/3573/
20211017
Welcome 陳羿妘(醫學) join us for undergraduate projects
20210928
榮獲陽明交通大學優良導師:)
20210920
Article accepted in Biosensors and Bioelectronics (EBV sensor)
20210909
Article accepted in PNAS (functions of EBER2)
20200901
Welcome 林榆涵、邱雅彙 join us
20200920
Welcome 陳一華(醫學) 呂韋萱(醫技) join us for undergraduate projects
20200815
Welcome 周壬渼、蔡若翎 join us
20200731
Welcome 張琳翔、張庭偉、陳一華、林得鴻for summer internship
20200701
Welcome陶定雨(生科)、劉子晴(醫技)、陳怡秀(醫技)、吳思賢(醫技) join us for undergraduate projects
20200226
Published in Journal of Virology (identify new EBV strains)
20200210
Welcome 林家安(醫技) 賴金承(醫學) join for undergraduate intern
20191230
Welcome 洪若寧(醫技) join us
20191105
Welcome TIGP PhD student Ivonne Lee(rotation)
20191026-31
International collaboration with Applied science and Pharmaceutical departments of TDTU (孫得勝大學)@ Vietnam.
20191001
The opening of R411's Website!
20190928
Whole Lab's database complete
榮獲陽明大學良師益友獎
20190930
Published in PloS One (functions of miRNA in EBV-transformed B cells isolated from patients).
20190906
Published in Nature Microbiology (ncRNA EBER regulates viral lytic replication and its effects on the environmental cells).
20190901
Welcome 毛翎, queen of 3D culture.
20190801
Welcome 李晉豪、蘇沛瑜、ChiaChia
2019July
Welcome summer students
Welcome international students
20190301
Welcome 張舒雅(醫技)
20190201
Published in Journal of Virology (EBV+ B cell movement).
20181101
Published in Plos Pathogens (EBV vaccine)
20180901
Welcome 翁立洋、洪瑄茌
20180815
Eventually our lab is ready to be used.
20180701
Welcome 5 Summer students
20180501
Congratulation! We won the MOST Young Scholar Fellowship!
20180301
Published in Nucleic Acids Research (new ORF of EBV)
-We are a very strong team for studying the viral genetics and the pathogenic roles of the giant virus. We use Epstein-Barr virus (EBV) as model. Our group leader, Dr. Ming-Han Tsai (蔡明翰) is exactly the person who had successfully constructed various standard EBV strains in the world (including all the carcinoma EBV strains).
-We have strong collaboration with different research groups and hospitals in Taiwan and globally and wish to eradicate the cancers caused by EBV in the next decades. At first, we are focusing on the pathogenic roles of EBV in gastric cancer and we will expand our research toward other EBV-associated carcinomas. Importantly, EBV is the last major human tumor virus that is still barely understood; so far we still don't have drugs or vaccines against EBV.
-Due to the strong techniques for constructing giant DNA virus, we are also genetically modifying these giant DNA viruses for different applications and seeking for the opportunities for the bio-pharmaceutical businesses.
-Meanwhile, we are also highly focusing on biotechnology and applied virology. Besides developing the novel antivirals to solve emerging and re-emerging viral diseases, we are also focusing on applying the nature of viruses in biotech and medicine.
-We sincerely invite the highly motivated students to join our research team and enjoy the researches together!
In The News
團隊簡介 Who we are?
“Harnessing the Power of Viruses to Transform Science and Health” 以病毒之力，推動科學與健康的革命
“Empowered by Viruses, Inspired by Discovery”
讓病毒成為力量，讓發現成為驅動
我們以病毒學研究為核心，輻射至免疫學、生物技術及應用病毒學等領域。核心目標是預防與治療病毒相關疾病，為人類健康尋找長遠解方。
我們的研究優勢包括巨型病毒、重組病毒、應用性病毒與免疫學。特別是在EB 病毒 (Epstein-Barr virus, EBV) 領域，我們具備高度技術能量，已建立多株重組高致癌性病毒株，為探索病毒致病機制與藥物開發奠定堅實基礎。
🦠 EB 病毒為什麼值得研究？
EB 病毒一旦感染，將終身潛伏於人體，並與多種人類癌症、自體免疫疾病及長新冠 (Long COVID) 相關；它能感染並永生化人類血液細胞，且基因體龐大、可供研究與應用的潛力無限。
🦠 那我們到底在做什麼？從「病毒的多重人格」說起：
a. 病毒很壞 ：
它們可迅速傳播、造成全球疫情，並持續突變、挑戰人類防線。→ 聚焦於致病機制及抗病毒藥物 (antivirals) 與疫苗開發，力求為防疫與治療提供新策略。
b. 病毒很有趣且強大：
它們擁有強大的宿主操控能力。→ 我們將病毒蛋白與基因應用於生物技術，發展新型工具與平台。
c. 病毒是雙面間諜 ：
能巧妙操縱與躲避免疫系統。→ 我們從病毒–免疫交互作用出發，探索免疫學核心問題。
d. 病毒操弄免疫組成 ：
深入理解可反向應用於免疫細胞調控與細胞治療。
e. 病毒調皮導致多樣性疾病(EB病毒為例) ：
與多種癌症與自體免疫疾病密切相關。→ 可延伸至癌症生物學與免疫耐受 (immune tolerance) 研究。
因此，好好研究一個病毒，不僅能成為防疫尖兵，更能為生醫科技與創新應用開啟新契機。病毒研究—如 EB 病毒，可橫向整合免疫學、尖端生物技術、癌症生物學、應用病毒學與抗病毒藥物開發，這正是我們的熱情所在，也是我們正在努力的方向。💡
Updating scientific news by using FB account, no actively updating here
Account: Ming-Han Tsai
EBV and human autoimmune disease had been confirmed
Science: clinical researches suggest that EBV as the leading cause for Multiple sclerosis
COVID-19 vaccine?
COVID-19 Pandemic-vaccine update
EBV is for the bad symptoms after COVID-19 infection!
COVID-19 Pandemic-EBV
EBV causes inflammation after COVID-19 infection!
COVID-19 Pandemic-EBV
Epstein-Barr virus reactivation may be the cause of long COVID symptoms
COVID-19 Pandemic-EBV
Level 3 COVID-19 epidemic alert!
COVID-19 Pandemic-EBV
https://news.google.com/covid19/map?hl=en-US&mid=/m/06f32&gl=US&ceid=US:en
Unfortunately, COVID-19 kills 1.5 millions now
COVID-19 Pandemic
https://www.who.int/emergencies/diseases/novel-coronavirus-2019
Human Herpesvirus may lead to bipolar, depression?
Activating Hpothalamic-pituitary-adernal axis!?
https://www.cell.com/iscience/pdf/S2589-0042(20)30372-2.pdf
https://www.medicalnewstoday.com/articles/322752#How-HHV-6-may-cause-depression,-bipolar
The Outbreak of new coronavirus (COVID-19), live photo
World Health Organization (WHO)
https://experience.arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd
NCTU+NYMU=YMCT?
We are going to unite with NCTU and become a new university in the next August. Well, YMC"A" perhaps is a simple one to remember? Sep, 18, 2019
The New version of CRISPR-Cas9 with low off-target effects.
Nature. Believe it or not, this CRISPR fused with a viral protein that makes it possible.
The outbreak of ASFV
Now only Japan and Taiwan are free from African Swine Fever virus that causes 100% death rate of the infected pigs. Sep, 01, 2019
The outbreak of ASFV (非洲豬瘟) in Taiwan
Few cases of ASFV (enveloped DNA virus) in swine were reported in Taiwan-2025 Oct!
1. Remind again: don't bring ANY meat product back to Taiwan.
2. ASFV "currently" has no evidence for causing human diseases.
3. ASFV can be inactivated if the meat had been fully cooked.
3. ASFV infection of pigs could lead to death (90%-100%).
For more information of ASFV, please read the following website
a. World Organisation for Animal Health (WOAH)
https://www.woah.org › tahm › 3.08.01_ASF.pdf
b. 公視-我們的島 非洲豬瘟特輯
https://ourisland.pts.org.tw/content/11687
保護豬豬。別讓滷肉飯變得很遙不可及。
之前口蹄疫20年的故事希望大家銘記。點此連結: 台灣疾管署事件回顧。
(備註：此病毒目前為動物病毒，目前尚無導致人類疾病證據，但對豬隻有巨大殺傷力，但基於病毒強大傳播特性，請大家遵照政府/農業部/疾管署等指示配合努力將此病毒從台灣根除)
The Receptor of Chikungunya had been identified.
Published in Nature and Cell. It's FHL1.
Nasopharyngeal Carcinoma is caused by specific EBV strain!
Why all people are EBV-positive but some of them get cancers? Now is the answer: certain EBV strains cause human carcinomas!
Human error leak of lab virus now a substantial probability.
The confirmation of EBV in autoimmine diseases
System lupus erythematosus (SLE), multiple sclerosis (MS), are considered caused by EBV infection right now. (Nature genetics)
