Tsai, Ming-Han (蔡明翰 老師)
"Tumor viruses, EBV, and viral biotechnology lab"
Let's eradicate the cancers caused by viruses together!
Recruiting new students now! 歡迎有研究熱誠的大專生及碩博生加入
國立陽明交通大學 微生物及免疫學研究所 蔡明翰老師 (建議用電腦觀看此網頁)
If you have questions for us, please don't hesitate to leave your message.
Events in R411
20211017
Welcome 陳羿妘(醫學) join us for undergraduate projects
20210928
榮獲陽明交通大學優良導師:)
20210920
Article accepted in Biosensors and Bioelectronics (EBV sensor)
20210909
Article accepted in PNAS (functions of EBER2)
20200901
Welcome 林榆涵、邱雅彙 join us
Congratulation 毛翎、李晉豪、蘇沛瑜graduate!
20210220
Welcome 呂韋萱(醫技) join us for undergraduate projects
20200920
Welcome 陳一華(醫學) join us for undergraduate projects
20200815
Welcome 周壬渼、蔡若翎 join us
20200731
Welcome 張琳翔、張庭偉、陳一華、林得鴻for summer internship
20200701
Welcome陶定雨(生科)、劉子晴(醫技)、陳怡秀(醫技)、吳思賢(醫技) join us for undergraduate projects
20200226
Published in Journal of Virology (identify new EBV strains)
20200210
Welcome 林家安(醫技)、莊筑甯(醫技)、余麗文(醫技)、賴金承(醫學) join us for undergraduate projects
20200120
Welcome TIGP PhD student Ivonne Lee join us
20191230
Welcome 洪若寧(醫技) join us
20191105
Welcome TIGP PhD student Ivonne Lee! (rotation)
20191026-31
International collaboration with Applied science and Pharmaceutical departments of TDTU (孫得勝大學)@ Vietnam.
20191001
The opening of R411's Website!
20190928
Whole Lab's database complete
榮獲陽明大學良師益友獎
20190930
Published in PloS One (functions of miRNA in EBV-transformed B cells isolated from patients).
20190906
Published in Nature Microbiology (ncRNA EBER regulates viral lytic replication and its effects on the environmental cells).
20190901
Welcome 毛翎, queen of 3D culture.
20190801
Welcome 李晉豪、蘇沛瑜、ChiaChia
2019July
Welcome summer students
Welcome international students
20190301
Welcome 張舒雅(醫技)
20190201
Published in Journal of Virology (EBV+ B cell movement).
20181101
Published in Plos Pathogens (EBV vaccine)
20180901
Welcome 翁立洋、洪瑄茌
20180815
Eventually our lab is ready to be used.
20180701
Welcome 5 Summer students
20180501
Congratulation! We won the MOST Young Scholar Fellowship! (哥倫布計畫得主)
20180301
Published in Nucleic Acids Research (new ORF of EBV)
Who we are?
We are a very strong team for studying the viral genetics and the pathogenic roles of the giant virus. We use Epstein-Barr virus (EBV) as model. Our group leader, Dr. Ming-Han Tsai (蔡明翰) is exactly the person who had successfully constructed the five standard EBV strains (total 7 strains) in the world (including all the carcinoma EBV strains). Meanwhile, our PI has the strong collaboration with Prof. Dr. Delecluse at DKFZ/Germany, who established the elegant system to modify the EBV viral genome.
We have strong collaboration with different research groups and hospitals in Taiwan and globally and wish to eradicate the cancers caused by EBV in the next decades. At first, we are focusing on the pathogenic roles of EBV in gastric cancer and we will expand our research toward other EBV-associated carcinomas. Importantly, EBV is the last major human tumor virus that is still barely understood; so far we still don't have drugs or vaccines against EBV.
Due to the strong techniques for constructing giant DNA virus, we are also genetically modifying these giant DNA viruses for different applications and seeking for the opportunities for the bio-pharmaceutical businesses.
Our researches are kindly supported by MOST Young Scholar Fellowship for 5 years. We sincerely invite the highly motivated students to join our research team and enjoy the researches together!
In The News
The New version of CRISPR-Cas9 with low off-target effects.
Nature. Believe it or not, this CRISPR fused with a viral protein that makes it possible.
NCTU+NYMU=YMCT?
We are going to unite with NCTU and become a new university in the next August. Well, YMC"A" perhaps is a simple one to remember? Sep, 18, 2019
The Receptor of Chikungunya had been identified.
Published in Nature and Cell. It's FHL1.
The outbreak of ASFV
Now only Japan and Taiwan are free from African Swine Fever virus that causes 100% death rate of the infected pigs. Sep, 01, 2019
The Outbreak of new coronavirus (COVID-19), live photo
World Health Organization (WHO)
https://experience.arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd
Human Herpesvirus may lead to bipolar, depression?
Activating Hpothalamic-pituitary-adernal axis!?
https://www.cell.com/iscience/pdf/S2589-0042(20)30372-2.pdf
https://www.medicalnewstoday.com/articles/322752#How-HHV-6-may-cause-depression,-bipolar
Human error leak of lab virus now a substantial probability.
Unfortunately, COVID-19 kills 1.5 millions now (2020/12/08)
COVID-19 Pandemic
https://www.who.int/emergencies/diseases/novel-coronavirus-2019
Please also visit our official website: Department of Microbiology and Immunology, National Yang-Ming University (IMI, NYMU)
請您也蒞臨我們官方網頁: 國立陽明大學 微生物及免疫學研究所(微免所) 蔡明翰老師 腫瘤癌症病毒及病毒生物科技實驗室
https://imi.ym.edu.tw/files/13-1255-32723.php
Nasopharyngeal Carcinoma is caused by specific EBV strain!
Why all people are EBV-positive but some of them get cancers? Now is the answer: certain EBV strains cause human carcinomas!
COVID-19 vaccine? (2021/10)
COVID-19 Pandemic-vaccine update
EBV is for the bad symptoms after COVID-19 infection! (2021/09)
COVID-19 Pandemic-EBV
EBV causes inflammation after COVID-19 infection! (2021/09)
COVID-19 Pandemic-EBV
Epstein-Barr virus reactivation may be the cause of long COVID symptoms (2021/06)
COVID-19 Pandemic-EBV
Level 3 COVID-19 epidemic alert! (2021/05)
COVID-19 Pandemic-EBV
https://news.google.com/covid19/map?hl=en-US&mid=/m/06f32&gl=US&ceid=US:en
EBV and human autoimmune disease had been confirmed (2022/01)
Science: clinical researches suggest that EBV as the leading cause for Multiple sclerosis
The confirmation of EBV in autoimmine diseases
System lupus erythematosus (SLE), multiple sclerosis (MS), are considered caused by EBV infection right now. (Nature genetics)