We are interested in understanding how tumor viruses, especially Epstein-Barr virus (EBV), causes human carcinomas. Beside nasopharyngeal carcinoma (NPC) that is absolutely associated with EBV infection, 10% of human gastric carcinoma are also found EBV-infected. In comparison to NPC that is mostly restricted in certain geographical areas, the EBV-associated gastric carcinoma (EBVaGC) can be identified throughout the world that may contribute to 100-thousand tumor cases annually. However, the roles of EBV in gastric cancers remain obscure. Our lab has the most state-of-art techniques to manipulate and investigate EBV. We will investigate the fundamental virology of EBV in gastric cells and the roles of EBV transcripts in EBVaGC. We are also investigating the mechanisms viruses in human malignancies that are associating to viral infection. For example: breast cancer, colorectal carcinoma, Cholangiocarcinoma, and autoimmune diseases (Lupus and Multiple Scleroses).

Meanwhile, we are also manipulating the tumor viruses for several applications. We have the unique technique that allows us to modify the giant DNA virus and transform these “terrible viruses” become the useful tools for human. You are welcome to join us and use the viruses to change the world.